Protective effects of vitamin E against liver damage caused by renal ischemia reperfusion. (2nd February 2015)

• Record Type: Journal Article
• Authors: Khastar, Hossein
• Is Part Of: Renal failure. Volume 37:Number 3(2015)
• Page Start: 494
• Page End: 496
• Publication Date: 2015-02-02
• Subjects: Liver damage -- remote organs -- renal ischemia -- reperfusion -- vitamin E; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2015.1006084
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Recent studies have reported that remote organs are affected by renal ischemia reperfusion (IR). The present study investigates the role of vitamin E on the liver damage after renal IR. First, male mice were subjected to three groups ( n = 9): 1) sham-operated, (2) renal IR (45 min ischemia), (3) renal IR + Vitamin E (150 mg/kg trough feeding tube for 28 d). After 24 h of reperfusion, animal were anesthetized for sample collections. Liver tissues malondialdehyde (MDA) increased and total glutathione (GSH) concentration decreased in the IR group compared to the sham group. Vitamin E consumption diminished the IR-induced increase in plasma AST and ALT. In addition, Vitamin E inhibited the IR-induced decrease in GSH activity and diminished IR-induced increase in MDA concentration. These findings showed that vitamin E consumption partly inhibited the IR-induced liver damage.