Two new triterpenes from Euphorbia alatavica. Issue 10 (3rd October 2017) - Rozimamat, Rushangul
Abstract: A phytochemical investigation on Euphorbia alatavica Boiss resulted in the isolation of nine compounds, including two new ones, alatavolide and alatavoic acid(1–2) . Chemical structures of these compounds were established on the basis of 1D, 2D NMR, and HR-MS techniques, and by comparison with data reported in the literature. Compounds1, 2, 4, 6, 8, and9 were screened for cytotoxicity using the MTT assay. Among these compounds, the new compound2 showed moderate cytotoxicity against Hela, MCF-7 and A549 cell lines (IC50 values of 16.4 ± 3.2, 14.5 ± 2.8, 22.3 ± 3.1 μM, respectively), while the known compound8 exhibited the most potent cytotoxicity with the IC50 values of 6.5 ± 3.1, 1.9 ± 0.9, 8.6 ± 3.5 μM, respectively. Abstract :