A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin. (4th May 2017)

• Record Type: Journal Article
• Authors: Serjeant, Graham R.; Serjeant, Beryl E.; Hambleton, Ian R.; Oakley, Matthew; Thein, Swee Lay; Clark, Barnaby
• Is Part Of: Hemoglobin. Volume 41:Number 3(2017)
• Page Start: 216
• Page End: 217
• Publication Date: 2017-05-04
• Subjects: Hereditary persistence of fetal hemoglobin (HPFH) genes -- Jamaica -- newborn screening -- school screening; Hemoglobinopathy -- Periodicals; Hemoglobin -- Periodicals; Hematology -- Periodicals; Thalassemia -- Periodicals; Blood -- Diseases -- Periodicals; 612.1111
• DOI: 10.1080/03630269.2017.1360336
• Languages: English
• ISSNs: 0363-0269

Abstract

Abstract: The gene for hereditary persistence of fetal hemoglobin (HPFH) in the Caribbean is much more common than previously estimated. To avoid labeling persons with the benign syndrome Hb S ( HBB : c.20A>T)/HPFH as a disease and wasting scarce resources, parental studies are recommended when newborn screening reveals a pattern consistent with an SS phenotype.