Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study. (2nd December 2017)

• Record Type: Journal Article
• Authors: Zhang, Xiaoni; Li, Yi; Li, Xiangpen; Rong, Xiaoming; Tang, Yamei; Peng, Ying
• Is Part Of: International journal of neuroscience. Volume 127:Number 12(2017)
• Page Start: 1059
• Page End: 1064
• Publication Date: 2017-12-02
• Subjects: Radiation-induced brain injury -- radiotherapy -- Dl-3-n-butylphthalide -- neurologic function protection -- clinical study; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2017.1310727
• Languages: English
• ISSNs: 0020-7454

Abstract

ABSTRACT: Purpose : To evaluate the neuroprotective effects of Dl-3-n-butylphthalide (NBP) on patients with radiation-induced brain injury, a hospital-based, clinical retrospective cohort study was conducted. Patients and m ethods : Data were collected on patients diagnosed with radiation-induced brain injury from January 2009 to January 2015 in Department of Neurology, Sun Yat-Sen Memorial Hospital. All patients enrolled have received cranial radiotherapy and were diagnosed with radiation-induced brain injury. Patients fulfilling certain eligibility criteria were recruited for analysis. The clinical therapeutic effects were observed and evaluated by LENT/SOMA scores before and one month after treatment in these two groups, respectively. Results : The therapeutic effects of headache (total efficiency 75.76%), eurologic deficit (total efficiency 81.58%), cognitive functions (total efficiency 77.78%) and MRI results (total efficiency 74.29%) were better in the experimental group than those in the control group ( p < 0.05). Nevertheless, there was no significant difference in mood and personality changes between these two groups. Conclusions : Administration of Dl-3-n-butylphthalide, in adjunct to corticosteroid therapy, might provide a better outcome in patients with radiation-induced brain injury.