Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation12. Issue 36 (5th September 2017)

• Record Type: Journal Article
• Authors: Rossi-Ashton, James A.; Taylor, Richard J. K.; Unsworth, William P.
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 36(2017)
• Page Start: 7527
• Page End: 7532
• Publication Date: 2017-09-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02039b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Three divergent procedures allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones from common imine and carboxylic acid precursors. Abstract : Three divergent Direct Imine Acylation (DIA) procedures are reported that allow the selective generation of δ-lactams, β-lactams and tetrahydropyrimidinones ( via a novel three-component coupling) from imine and carboxylic acid precursors. All operate via initial N -acyliminium ion formation and diverge depending on the reaction conditions and nature of the substrates.