Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters. Issue 36 (16th August 2017)

• Record Type: Journal Article
• Authors: Afonso, Damien; Valetti, Sabrina; Fraix, Aurore; Bascetta, Claudia; Petralia, Salvatore; Conoci, Sabrina; Feiler, Adam; Sortino, Salvatore
• Is Part Of: Nanoscale. Volume 9:Issue 36(2017)
• Page Start: 13404
• Page End: 13408
• Publication Date: 2017-08-16
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr04832g
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Mesoporous silica nanoparticles release NO under light control and exploit the embedded carbon dots as fluorescence reporters for the NO liberated. Abstract : Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD ) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robustMSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched inMSCD-1 by effective energy transfer. Visible light excitation ofMSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of theMSCD scaffold, which acts as an optical reporter for the released NO. TheMSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.