A dinuclear copper(i) thiodiacetate complex as an efficient and reusable 'click' catalyst for the synthesis of glycoconjugates. Issue 37 (15th September 2017)

• Record Type: Journal Article
• Authors: Sareen, Neha; Singh, Anoop S.; Tiwari, Vinod K.; Kant, Rajni; Bhattacharya, Subrato
• Is Part Of: Dalton transactions. Volume 46:Issue 37(2017)
• Page Start: 12705
• Page End: 12710
• Publication Date: 2017-09-15
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c7dt02346d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A novel Cu(i ) complex as an efficient and reusable homogeneous "click" catalyst. Abstract : We report herein the facile synthesis and structural characterization of a highly stable dinuclear Cu(i ) complex, [(PPh3 )2 Cu(μ-tda)Cu(PPh3 )2 ]·6H2 O1 (tda = thiodiacetate anion), in which the Cu–Cu distance is 7.197 Å. This "pre-formed" complex serves as an extremely efficient and recyclable homogeneous catalyst (2 mol%, 30 min) for CuAAC in dichloromethane solvent. The synthesis of a variety of glycoconjugates under ambient conditions is successfully achieved using1 as a catalyst. The products are obtained in high yields and very short reaction times while complying with the "click protocols". A simpler procedure solely involving the mixing of substrates with1 ( i.e. base free and solvent free) gave the corresponding glycoconjugate in 10 min using 2 mol% of the catalyst.