High magnetic relaxivity in a fluorescent CdSe/CdS/ZnS quantum dot functionalized with MRI contrast molecules. Issue 76 (22nd August 2017)

• Record Type: Journal Article
• Authors: McAdams, S. G.; Lewis, D. J.; McNaughter, P. D.; Lewis, E. A.; Haigh, S. J.; O'Brien, P.; Tuna, F.
• Is Part Of: Chemical communications. Volume 53:Issue 76(2017)
• Page Start: 10500
• Page End: 10503
• Publication Date: 2017-08-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc05537d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Fluorescent quantum dots functionalized with Gd(iii ) MRI contrast agents produce an unprecedentedly high T 1 relaxivity per particle (6800 mM −1 s −1 ). Abstract : Light emitting semiconducting quantum dots show great promise as solar cells, optoelectronic devices and multimodal imaging probes. Here we demonstrate successful grafting of a thiol-functionalised Gd III MRI contrast agent onto the surface of core-multishell CdSe/CdS/ZnS quantum dots. The resulting nanoprobe exhibits intense photoluminescence and unprecedentedly large T 1 relaxivity of 6800 mM −1 s −1 per nanoparticle due to secure implanting of ca. 620 magnetic centers per quantum dot unit.