Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense. Issue 63 (16th August 2017)

• Record Type: Journal Article
• Authors: Wu, Yue-Hua; Zhang, Zhi-Han; Zhong, Yue; Huang, Jun-Jun; Li, Xiao-Xia; Jiang, Jin-Yan; Deng, Yin-Yue; Zhang, Lian-Hui; He, Fei
• Is Part Of: RSC advances. Volume 7:Issue 63(2017)
• Page Start: 40015
• Page End: 40019
• Publication Date: 2017-08-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra06933b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Four new curvularin-type macrolides were isolated from a marine fungus Penicillium Sumatrense and their absolute configurations were determined by CD spectra and modified Mosher's methods. Abstract : Sumalactones A–D (1–4 ), four new curvularin-type macrolides, together with two known analogues, curvularin (5 ) and dehydrocurvularin (6 ), were isolated from Penicillium Sumatrense, a marine fungus isolated from deep-sea sediments. Sumalactones C (3 ) and D (4 ) are unprecedented curvularin-type macrolides bearing a rare 11-membered macrolide skeleton. Their structures were elucidated on the basis of intensive spectroscopic analysis. The absolute configurations of compounds1–4 were determined by CD spectra and modified Mosher's method. Compound6 showed significant inhibition activity towards LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 0.91 μM.