A novel water-soluble AIE-based fluorescence probe with red emission for the sensitive detection of heparin in aqueous solution and human serum samples. Issue 37 (13th September 2017)

• Record Type: Journal Article
• Authors: Yang, Shuqi; Gao, Tang; Dong, Jie; Xu, Huan; Gao, Feng; Chen, Qian; Gu, Yonghong; Zeng, Wenbin
• Is Part Of: Tetrahedron letters. Volume 58:Issue 37(2017)
• Page Start: 3681
• Page End: 3686
• Publication Date: 2017-09-13
• Subjects: Heparin detection -- Aggregation-induced emission -- Long wavelength emission -- Water-solubility -- Human serum samples; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.08.023
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An novel AIE-based compoundTIBI was successfully designed and synthesized. TIBI exhibited great solubility in aqueous solution. TIBI could detect heparin with very low detection limit (0.08 μM). TIBI could exhibit red light emission (650 nm) while interacting with heparin. TIBI could be successfully applied to detect heparin in human serum samples. Abstract: Heparin is widely used to anticoagulation treatment in clinic, while the overdoses of heparin can cause potentially catastrophic complications. Thus, the selective and sensitive detection of heparin is of great importance. Herein, a novel water-soluble AIE-based fluorescent probe (TIBI) with red emission (650 nm) has been rationally developed to detect heparin by the electrostatic-interaction and ion replacing strategy.TIBI exhibited excellent selectivity and low detection limit (0.08 μM) for detection of heparin. Moreover, TIBI was successfully applied to detect heparin in complicated serum samples with satisfactory results. This study holds great promise for real time monitoring heparin in clinical application.