A metal-free three components procedure for the synthesis of perfluoroalkyl substituted amidines. Issue 38 (20th September 2017)

• Record Type: Journal Article
• Authors: Ai, Han-Jun; Cai, Chuang-Xu; Qi, Xinxin; Peng, Jin-Bao; Ying, Jun; Zheng, Feng; Wu, Xiao-Feng
• Is Part Of: Tetrahedron letters. Volume 58:Issue 38(2017)
• Page Start: 3751
• Page End: 3753
• Publication Date: 2017-09-20
• Subjects: Amidine -- Perfluoroalkyl iodides -- Isocyanides -- Metal-free -- Green chemistry; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.08.038
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Interesting multicomponent procedure for perfluoroalkyl substituted amidines synthesis. With readily avaliable perfluoroalkyl iodides, tert -butyl isocyanides and amines as substrates. No transition-metal catalyst, additional ligands and additives were required. Radical pathway. Abstract: An interesting multicomponent reaction for the synthesis of perfluoroalkyl substituted amidines has been developed. By using perfluoroalkyl iodides, tert -butyl isocyanides and amines as the substrates, the reactions proceed via somophilic isocyanide insertion. In this catalytic system, no transition-metal catalyst, additional ligands and additives were required. The reaction proceed smoothly and a variety of desired amidines were obtained in moderate to excellent yields.