Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum. Issue 40 (5th October 2017)

• Record Type: Journal Article
• Authors: Chen, Li; Zhao, Yang-Yang; Lan, Rong-Feng; Du, Lin; Wang, Bing-Shuai; Zhou, Tong; Li, Ya-Ping; Zhang, Qi-Qing; Ying, Min-Gang; Zheng, Qiu-Hong; Liu, Qin-Ying
• Is Part Of: Tetrahedron. Volume 73:Issue 40(2017)
• Page Start: 5900
• Page End: 5911
• Publication Date: 2017-10-05
• Subjects: Marine-derived fungus -- Polyketide -- Structure elucidation -- Conformation analysis -- Microtubule-destabilizing; XGSFTGPACVBVKR-LDYMZIIASA-N; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.08.032
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Dicitrinone D is a novel polyketide isolated from a marine-derived fungus Penicillium citrinum . In this study, we described the isolation, structure elucidation and antitumor mechanism of this compound. Cell proliferation assay showed that dicitrinone D was safe for normal cells, but effectively inhibited the growth of multiple tumor cells, especially SPC-A1 cells. Cell cycle and immunofluorescence analysis suggested that dicitrinone D had cellular effects similar to other microtubule-targeting agents. Polymerization assay, electron microscopy and time-lapsed video microscopy assay demonstrated dicitrinone D was a microtubule-destabilizing agent. Finally, the docking analysis predicted that dicitrinone D may bind to vinblastine binding site on tubulin. Graphical abstract: