Improved biooxidation of Benzyl alcohols catalyzed by the flavoprotein (5-Hydroxymethyl)furfural oxidase in organic solvents. Issue 36 (7th September 2017)

• Record Type: Journal Article
• Authors: Pickl, Mathias; Jost, Etta; Glueck, Silvia M.; Faber, Kurt
• Is Part Of: Tetrahedron. Volume 73:Issue 36(2017)
• Page Start: 5408
• Page End: 5410
• Publication Date: 2017-09-07
• Subjects: Biocatalysis -- HMF-oxidase -- O2-oxidation -- Organic solvent -- Benzylic alcohol; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.07.038
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The biooxidation of benzylic alcohols catalyzed by (5-hydroxymethyl)furfural oxidase (HMFO) to the corresponding benzaldehydes or benzoic acids was investigated in the presence of various organic (co)solvents. Whereas the enzyme activity decreased at elevated concentrations of water-miscible polar solvents, the presence of (halogenated) hydrocarbons was tolerated up to 90% (v/v), which led to drastically improved conversions of up to >99% in case of hexafluorobenzene. This remarkable effect was correlated with the improved solubility of O2 in the employed solvents. Reaction rates were boosted by O2 -saturation of solvents. Graphical abstract: