Novel quinoxaline derivative: Solubilization by surfactant solutions and membranotropic properties. Issue 34 (24th August 2017)

• Record Type: Journal Article
• Authors: Mirgorodskaya, Alla B.; Valeeva, Farida G.; Gabdrakhmanov, Dinar R.; Mustakimova, Liliya V.; Zakharova, Lucia Ya.; Sinyashin, Oleg G.; Mamedov, Vakhid A.
• Is Part Of: Tetrahedron. Volume 73:Issue 34(2017)
• Page Start: 5115
• Page End: 5121
• Publication Date: 2017-08-24
• Subjects: Quinoxaline -- Solubility -- Surfactant -- Membranotropic properties; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.07.002
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Novel compound, ( E )-3-([1, 2, 4]triazolo[4, 3- a ]quinoxalin-4(5 H )-on-1-yl)acrylic acid, containing triazole and quinoxaline moieties has been synthesized and characterized. The solubility of the compound in water and surfactant solutions has been estimated at different pH. It has been shown that the increase in solubility is due to hydrophobic effect as well as electrostatic interactions. The capability of this compound to integrate within dipalmitoylphosphocholine lipid bilayer has been evaluated. An increase in membranotropic properties after encapsulation of this compound in nanocontainers based on dicationic surfactant has been exhibited. Graphical abstract: