Ibuprofen-loaded PCL meshes manufactured using rapid tooling for ocular orbital repair. (September 2017)

• Record Type: Journal Article
• Authors: Salmoria, Gean V.; Sibilia, Francesca; Gindri, Izabelle M.; Roesler, Carlos R.M.; Farè, Silvia; Tanzi, Maria C.
• Is Part Of: Polymer testing. Volume 62(2017)
• Page Start: 33
• Page End: 40
• Publication Date: 2017-09
• Subjects: PCL/Ibuprofen meshes -- Orbital repair -- Injection molding -- Rapid tooling; Polymers -- Testing -- Periodicals; Polymères -- Tests -- Périodiques; 620.1920287
• DOI: 10.1016/j.polymertesting.2017.06.009
• Languages: English
• ISSNs: 0142-9418

Abstract

Abstract: This study investigated the manufacture of resorbable polycaprolactone/ibuprofen (PCL/IBP) meshes by injection molding for application in ocular orbital repair. The pore dimension sizes used demonstrate that micro-porous meshes can be manufactured by injection molding using a prototype mold. The mechanical properties were observed to be dependent on the material composition and morphology. Lower stiffness, strength and elongation at failure were observed for the 8 mm pore sized samples. The PCL/Ibuprofen meshes initially showed a fast drug release but after 3 days the release was slow and controlled. The cytotoxicity test results of the PCL/Ibuprofen meshes indicated that the large initial quantity of Ibuprofen released was too high and resulted in cell toxicity. However, after this initial release, the PCL/Ibuprofen meshes showed a good interaction with the cells seeded on their surface. The presence of a low concentration of Ibuprofen does not negatively influence cell viability in culture.