Associations between the levels of soluble (pro)renin receptor in maternal and umbilical cord blood and hypertensive disorder of pregnancy. (September 2017)

• Record Type: Journal Article
• Authors: Mikami, Yukiko; Takai, Yasushi; Narita, Tatsuya; Era, Sumiko; Ono, Yoshihisa; Saitoh, Masahiro; Baba, Kazunori; Matsuoka, Kikumi; Seki, Hiroyuki
• Is Part Of: Placenta. Volume 57(2017:Sep.)
• Page Start: 129
• Page End: 136
• Publication Date: 2017-09
• Subjects: (pro)renin receptor -- Prorenin -- Hypertensive disorder of pregnancy; RAS renin-angiotensin system -- HDP hypertensive disorder of pregnancy -- (P)RR (pro)renin receptor -- s(P)RR soluble (pro)renin receptor -- PR prorenin -- FGR fetal growth restriction -- CE coefficient estimate; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2017.06.342
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Introduction: The prorenin (PR) receptor [(P)RR] contributes to the regulation of the tissue renin-angiotensin system (RAS) and Wnt signaling, which is involved in embryogenesis and the pathological progression of malignant tumors and diabetes mellitus. Placental (P)RR is significantly upregulated in placental tissues from preeclamptic women. However, because it cannot be examined during pregnancy, the chronological relationship between the acceleration of tissue RAS and the disease state of hypertensive disorder of pregnancy (HDP) has not been reported. In this study, we examined whether chronological changes in placental tissue RAS can be assessed by measuring soluble (P)RR [s(P)RR]. Methods: We obtained maternal and umbilical cord blood samples from 517 pregnant women (441 singleton and 76 twin pregnancies). The concentrations of s(P)RR and prorenin (PR) were measured using enzyme-linked immunosorbent assays. Results: Multivariate analysis showed that maternal serum s(P)RR levels were significantly higher in patients with HDP or fetal growth restriction (FGR) and were positively correlated with serum PR levels. Furthermore, the maternal s(P)RR level was significantly higher in HDP with severe hypertension and after the onset of HDP. However, maternal s(P)RR levels were not affected by the severity of proteinuria. Serum s(P)RR levels in umbilical cord blood of singleton pregnancies were significantly correlated with gestational week at delivery and PR level. Discussion: Maternal serum s(P)RR concentrations may reflect acceleration of tissue RAS in the placenta and blood pressure severity; however, the umbilical serum s(P)RR concentration was not affected by maternal HDP. Highlights: We examined soluble PR receptor [(P)RR] in hypertensive disorders of pregnancy. Maternal serum s(P)RR levels were higher in patients with HDP and FGR. Maternal s(P)RR levels may reflect accelerated tissue RAS in the placenta in HDP. Umbilical serum s(P)RR level was not affected by infant condition or maternal HDP.