Association between PARK16 and Parkinson's disease: A meta-analysis. (14th September 2017)

• Record Type: Journal Article
• Authors: He, Tao; Wang, Jie; Wang, Xiaoli; Deng, Wenshuai; Jiang, Hong; Xie, Junxia; Sun, Peng
• Is Part Of: Neuroscience letters. Volume 657(2017)
• Page Start: 179
• Page End: 188
• Publication Date: 2017-09-14
• Subjects: Parkinson's disease -- PARK16 -- RAB7L1 -- Meta-analysis -- LRRK2; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.08.022
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: We performed a meta-analysis to assess association between PARK16 and Parkinson's disease. PARK16 locus rs947211 polymorphism (A allele, AG and GG genotype) may be a protective factor for PD in overall populations, particularly in Northeast Asian populations. RAB7L1gene rs1572913 polymorphism (T allele, TC and TT genotype) was associated with decreased risk of PD. Abstract: Recent years, several case-control studies reported that two polymorphisms (rs947211 and 1572913) within the PARK16 locus were associated with the Parkinson's disease (PD). However, the results were still controversial. Herein, we conducted a comprehensive meta-analysis to estimate the associations between two polymorphisms and PD. Seven databases (PubMed, Google Scholar, EMBASE, Web of Science, CNKI (China National Knowledge Infrastructure), VIP and Wanfang) were searched to identify the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of two polymorphisms with PD susceptibility. Totally, 15 studies with 6637 cases and 6774 controls were included in our meta-analysis. The results showed that rs947211 variants were associated with a decreased risk of PD in overall population. Stratified analysis found that rs947211 variants were associated with a significantly decreased risk of PD in Northeast Asian population, but a slightly decreased risk of PD in Southeast Asian and Caucasian population. With regard to rs1572913 polymorphism, the results suggested that rs1572913 variants contribute to decrease the risk of PD. Therefore, our meta-analysis suggested that rs947211 variants (A allele, AG and GG genotypes) may decrease the risk of PD in overall population, particularly in Northeast Asian population; and T allele, TC and TT genotypes of rs1572913 variants contributed to decrease the risk of PD.