Anti-inflammatory activity of natural stilbenoids: A review. (October 2017)

• Record Type: Journal Article
• Authors: Dvorakova, Marcela; Landa, Premysl
• Is Part Of: Pharmacological research. Volume 124(2017:Oct.)
• Page Start: 126
• Page End: 145
• Publication Date: 2017-10
• Subjects: AMPK 5′ adenosine monophosphate-activated protein kinase -- AP-1 activator protein 1 -- CAT catalase -- COX cyclooxygenase -- CRP C-reactive protein -- CSA cajaninstilbene acid -- CYP cytochrome enzyme -- DSS dextran sulfate sodium -- ERK extracellular signal-regulated protein kinase -- GPCR G protein-coupled receptor -- GR glutathione reductase -- HO-1 heme oxygenase-1 -- HDL high density lipoprotein -- ICAM-1 intracellular adhesion molecule 1 -- IgE immunoglobulin E -- IKK I kappa B kinase -- IL interleukin -- iNOS inducible nitric oxide synthase -- JNK Jun amino-terminal kinase -- LDL low density lipoprotein -- LOX lipoxygenase -- LPS lipopolysacharides -- MAPK mitogen-activated protein kinase -- MDA malondialdehyde -- MMP matrix metallopeptidase -- mPGES-1 microsomal prostaglandin E synthase-1 -- NFAT nuclear factor of activated T-cells -- NF-κB nuclear factor kappa B -- NHEK normal human epidermal keratinocytes -- NLC nanostructured lipid carrier -- NO nitric oxide -- NOX NADPH oxidase -- Nrf2 nuclear factor erythroid 2-related factor 2 -- NSAID nonsteroidal anti-inflammatory drug -- OHDA 6-hydroxydopamine -- PAMP pathogen-associated molecular pattern -- PGD2 prostaglandin D2 -- PGE2 prostaglandin E2 -- PKC protein kinase C -- PMA phorbol-12-myristate-13-acetate -- PME pinosylvin monomethyl ether -- PPARα peroxisome proliferator-activated receptor α -- ROS reactive oxygen species -- SLN solid lipid nanoparticle -- SOD superoxide dismutase -- STAT-1 signal transducer and activator of transcription-1 -- Syk spleen tyrosine kinase -- TMS 3, 5, 4′-trans-trimethoxystilbene -- TNFα tumor necrosis factor α -- TPA 12-O-tetradecanoylphorbol-13-acetate -- VCAM-1 vascular cell adhesion molecule 1 -- VPO1 vascular peroxidase 1; Inflammation -- Natural stilbenes -- Multi-targeted therapy -- Metabolites -- Bioavailability -- Encapsulation; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2017.08.002
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Resveratrol and other natural stilbenoids, including piceatannol, pterostilbene, and gnetol, are well-known anti-inflammatory compounds with indisputable activity in vitro as well as in vivo . Their molecular targets include inducible nitric oxide synthase, cyclooxygenases, leukotrienes, nuclear factor kappa B, tumor necrosis factor α, interleukins and many more. This anti-inflammatory activity together with their antioxidant activity is believed to stand behind their other positive health effects against cancer, cardiovascular and neurodegenerative diseases or diabetes. Thus, they are nowadays commercially marketed as nutraceuticals. Naturally, they are present in wine, grapes or berries. However, there is a rigorous debate about the real effect of these compounds on human health. It is argued that the concentration of stilbenoids in food and beverages is too low to have any therapeutic potential and this concentration is further reduced by their low bioavailability and extensive metabolism. Therefore, this review focuses on in vitro, in vivo, preclinical as well as clinical data available for various natural stilbenoids and summarizes the anti-inflammatory targets on molecular level, compares the relevance of the experimental studies, discusses the metabolism of stilbenoids and the potential activity of their metabolites and relates this knowledge to human health. Moreover, the ways to augment stilbenoidś efficacy are suggested with special focus on multitargeted therapy and nanocarriers.