Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila‐infected crucian carp (Carassius auratus gibelio). Issue 5 (15th February 2017)

• Record Type: Journal Article
• Authors: Fan, J.; Shan, Q.; Wang, J.; Liu, S.; Li, L.; Zheng, G.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 40:Issue 5(2017)
• Page Start: 580
• Page End: 582
• Publication Date: 2017-02-15
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12392
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract : The comparative pharmacokinetics of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated in healthy and Aeromonas hydrophila ‐infected crucian carp after a single oral (p.o.) administration at a dose of 10 mg/kg at 25 °C. The plasma concentrations of ENR and of CIP were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR concentrations by noncompartmental modeling. In healthy fish, the elimination half‐life ( T 1/2 λ z ), maximum plasma concentration ( C max ), time to peak ( T max ), and area under the concentration–time curve (AUC) values were 64.66 h, 3.55 μg/mL, 0.5 h, and 163.04 μg·h/mL, respectively. In infected carp, by contrast, the corresponding values were 73.70 h, 2.66 μg/mL, 0.75 h, and 137.43 μg·h/mL, and the absorption and elimination of ENR were slower following oral administration. Very low levels of CIP were detected, which indicates a low extent of deethylation of ENR in crucian carp.