Efficient [Cu(NHC)]‐Catalyzed Multicomponent Synthesis of Pyrroles. Issue 18 (17th August 2017)

• Record Type: Journal Article
• Authors: Dang, Tuan Thanh; Seayad, Abdul Majeed
• Is Part Of: Chemistry, an Asian journal. Volume 12:Issue 18(2017)
• Page Start: 2383
• Page End: 2387
• Publication Date: 2017-08-17
• Subjects: copper -- dehydrogenation -- N-heterocyclic carbenes -- nitrogen heterocycles -- pyrrole synthesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201701045
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Efficient [Cu(NHC)]‐catalyzed syntheses of pyrroles via two and three‐component coupling methods are described. Various 1, 2‐, 1, 2, 3‐, 1, 2, 3, 5‐ and fully substituted pyrroles were readily accessible through a suitable choice of ketone, primary amine and diol in a three‐component reaction. The N‐unsubstituted pyrrole formation is also feasible through a two‐component reaction involving a β‐amino alcohol and a ketone. Abstract : Pyrrole‐mania ! A [Cu(NHC)] (NHC=N‐heterocyclic carbene) catalyst efficiently converts readily available diols, ketones, β‐amino alcohols, and amines to various substituted pyrroles through a two‐ or three‐component reaction in up to 95 % isolated yield.