A perspective on malignancy in the marrow. Issue 12 (16th May 2017)

• Record Type: Journal Article
• Authors: Reagan, Michaela R.; Lian, Jane B.; Rosen, Clifford J.; Stein, Gary S.
• Is Part Of: Journal of cellular physiology. Volume 232:Issue 12(2017:Dec.)
• Page Start: 3218
• Page End: 3220
• Publication Date: 2017-05-16
• Subjects: bone marrow niche -- bone metastasis -- microenvironment -- tumor; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.25860
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Malignancies that grow in the bone marrow cause a cascade of devastating consequences and are almost always fatal. For researchers to make significant headway in finding cures and treatments for these tumors and the subsequent devastation of cancer‐induced bone disease, novel strategies and creative solutions will have to be considered. Great progress has been made in treating hematologic and sold tumor malignancies that ultimately affect the bone marrow, although it is also obvious that multi‐disciplinary teams are required to ultimately win the war on cancers that affect the bone. In this perspective, we review recent advances in the identification of molecular and cellular targets in the bone marrow niche.