Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. (September 2017)

• Record Type: Journal Article
• Authors: Zhu, Di; Zhang, Xinglin; Niu, Yajie; Diao, Zhijun; Ren, Bo; Li, Xingyu; Liu, Zhigang; Liu, Xuebo
• Is Part Of: Food and chemical toxicology. Volume 107:Part A(2017)
• Page Start: 138
• Page End: 149
• Publication Date: 2017-09
• Subjects: Cichoric acid -- Hyperglycaemia -- MLD-STZ -- Mitochondrial biogenesis -- Glycogen synthesis -- Inflammatory; AMPK AMP-activated kinase -- AUC Area under curve -- CA Cichoric acid -- COXII Cytochrome c oxidase subunit II -- Cox-2 cyclooxygenase-2 -- DM Diabetes mellitus -- GLUT2 glucose transporter 2 -- H&E haematoxylin and eosin -- HOMA-IR homeostasis model assessment of insulin resistance -- Il-1β interleukine-1β -- Inos inducible nitric oxide synthase -- IR insulin receptor -- IRS insulin receptor substrate 1 -- Isl1 Islet1 -- JNK c-Jun N-terminal kinase -- MAPKs mitogen-activated protein kinases -- MLD-STZ multiple low doses of STZ -- Ngn3 neurogenin 3 -- Neurod1 Neurogenic differentiation 1 -- PAS periodic acid-schiff -- STZ streptozotocin -- Sirt1 Sirtuin 1 -- SOCS3 cytokine signaling 3 -- Tfam Mitochondrial transcription factor -- Tnf-α tumour necrosis factor -- PDX-1 Pancreatic and Duodenal Homeobox-1 -- Pgc1-a Peroxisome proliferator-activated receptor coactivator 1-a -- PTEN gene of phosphate and tension homology deleted on chromsome ten -- PTP1B protein tyrosine phosphates 1B; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2017.06.041
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Cichoric acid (CA), extracted from edible plants and vegetables, is a potential natural nutraceutical, with antioxidant and hypoglycaemic biological functions. The objective of this study was to explore the potential underlying molecular mechanisms involved in normalizing diabetes-related changes in hyperglycaemia via pancreas apoptosis and muscle injury induced by multiple low-dose STZ (MLD-STZ) injection in response to dietary supplementation with CA. To induce the MLD-STZ diabetic mice, the C57BL/6J mice were intraperitoneally injected with STZ (50 mg/kg body weight) for consecutive five days. CA (60 mg/kg/d) was supplemented in drinking water for 4 weeks. Compared with control, CA inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Moreover, CA regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses, which contributes to the improvement in athletic ability and diabetic myopathy. In general, CA is a natural food-derived compound with the potential application for regulating glucose homeostasis and improving diabetes and its complications. Graphical abstract: Highlights: CA regulates hyperglycaemia in STZ-induced diabetic mice. CA reversed pancreatic cells apoptosis and improved insulin secretion. CA improves athletic ability and regulated mitochondrial biogenesis. CA regulated glycogen synthesis via reversing insulin resistance. CA suppressed muscle inflammation via activating antioxidant response.