Current trials to reduce surgical intervention in ductal carcinoma in situ of the breast: Critical review. (October 2017)

• Record Type: Journal Article
• Authors: Toss, M.; Miligy, I.; Thompson, A.M.; Khout, H.; Green, A.R.; Ellis, I.O.; Rakha, E.A.
• Is Part Of: Breast. Volume 35(2017)
• Page Start: 151
• Page End: 156
• Publication Date: 2017-10
• Subjects: Breast -- Duct carcinoma in situ -- DCIS -- Management; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2017.07.012
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: The high proportion of ductal carcinoma in situ (DCIS) presented in mammographic screening and the relatively low risk of progression to invasive disease have raised questions related to overtreatment. Following a review of current DCIS management protocols a more conservative approach has been suggested. Clinical trials have been introduced to evaluate the option of avoiding surgical intervention in a proportion of patients with DCIS defined as "low-risk" using certain clinicopathological criteria. These trials can potentially provide evidence-based models of active surveillance (with or without endocrine therapy) as a future management approach. Despite the undisputable fact of our need to address the obvious overtreatment of screen-detected DCIS, some important questions need to be considered regarding these trials including the eligibility criteria and definition of risk, the proportion of patient eligible for inclusion, and the length of time required for proper analysis of the trials' outcome in view of the long-term natural history of DCIS progression particularly the low-risk group. These factors can potentially affect the practicality and future impact of such trials. This review provides critical analysis of current DCIS management trials and highlights critical issues related to their practicality and the expected outcome.