Synthesis, Conformational Properties and DFT Computational Studies of Polymethyl‐Substituted [3.3]Metacyclophanes. Issue 24 (23rd August 2017)

• Record Type: Journal Article
• Authors: Islam, Md. Monarul; Akther, Thamina; Rahman, Shofiur; Georghiou, Paris E.; Matsumoto, Taisuke; Tanaka, Junji; Redshaw, Carl; Yamato, Takehiko
• Is Part Of: ChemistrySelect. Volume 2:Issue 24(2017)
• Page Start: 7255
• Page End: 7262
• Publication Date: 2017-08-23
• Subjects: Anti-syn isomerisation -- Conformation -- DFT calculations -- Metacyclophanes -- Wolff–Kishner reduction; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701243
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Polymethyl substituted [3.3]metacyclophanes (MCPs)4 a–d, were synthesized by the TosMIC coupling method followed by Wolff–Kishner reduction of the corresponding polymethyl‐substituted [3.3]MCP‐2, 11‐diones (3 a–d ). 1 H NMR spectroscopy reveals that both 5, 6, 7, 14, 16‐pentamethyl[3.3]MCP‐2, 11‐diones (3 a and3 b ) undergo conformational changes relative to the NMR time scale in solution at room temperature but that the anti conformer is preferred. Reduced 5, 6, 7, 14, 16‐pentamethyl[3.3]MCP (4 a and4 b ) adopt fixed syn– conformations in solution at room temperature. X‐ray analysis showed that in the solid state, 5, 6, 7, 14, 15, 16‐hexamethyl[3.3]MCP‐2, 11‐dione3 a adopts the anti ‐conformation and reduced 5, 6, 7, 14, 16‐pentamethyl[3.3]MCP‐2, 11‐diones4 b adopts a syn‐ (chair‐chair) conformation. A series of electrophilic substitution reactions such as formylation, acetylation and nitration were carried out with 5, 6, 7, 14, 16‐pentamethyl[3.3]MCP4 b to study their conformational isomers. The formyl, acetyl and nitro derivatives of 5, 6, 7, 14, 16‐pentamethyl[3.3]MCP are fixed to adopt syn ‐conformations in solution at room temperature. The conformational isomers of the metacyclophanes and derivatives obtained from density functional theory (DFT) methods were used to estimate the total energies and energy minimized structures of the different conformations. Abstract : Medium sized polymethyl substituted [3.3]metacyclophanes were synthesized by a TosMIC coupling method followed by Wolff–Kishner reduction and the energy minimized structures of the different conformations were studied by DFT. A series of electrophilic substitution reactions such as formylation, acetylation and nitration were carried out to study the conformational isomers.