A New Chirally Organized Trifluoromethylanthrylmethanol Derivative and Its Application as Chiral Solvating Agent. Issue 24 (28th August 2017)

• Record Type: Journal Article
• Authors: Monteagudo, Eva; de March, Pedro; Álvarez‐Larena, Ángel; Virgili, Albert
• Is Part Of: ChemistrySelect. Volume 2:Issue 24(2017)
• Page Start: 7362
• Page End: 7367
• Publication Date: 2017-08-28
• Subjects: BINOL -- Chiral Solvating Agents -- enantiodifferentiation -- NMR -- spectroscopy; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201701429
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The synthesis and structure of 1, 1′‐(((10, 10'‐(1, 1′‐binaphthalene)‐2, 2′‐diylbis(oxy))bis(methylene))bis(anthracene‐10, 9‐diyl))bis(2, 2, 2‐trifluoroethanol), 4, is reported. This compound owns both axial and central chirality allowing its use as a chiral solvating agent (CSA) for the enantiomeric composition determination of several mixtures of chiral aromatic alcohols and amines using NMR. The study of the resulting diastereoisomeric complexes was carried out by determining its stoichiometry and association binding constants. Abstract : NMR enantiodifferentiation: A new trifluoromethylanthrylmethanol derivative chirally organized was synthetized and its application as chiral solvating agent (CSA) for the enantiodiscrimination of chiral amines and alcohols was demonstrated.