Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity. Issue 16 (November 2017)

• Record Type: Journal Article
• Authors: Capela, M.N.; Tobaldi, D.M.; Oliveira, C.; Pereira, A.; Duarte, A.S.; Seabra, M.P.; Fernandes, M.H.V.
• Is Part Of: Ceramics international. Volume 43:Issue 16(2017)
• Page Start: 13800
• Page End: 13809
• Publication Date: 2017-11
• Subjects: Glass -- Glass-ceramic -- Bioactive -- Silver -- Antibacterial; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2017.07.100
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli . A melt-quenched bioactive glass of the SiO2 -CaO-P2 O5 -MgO system was modified with the addition of 1 and 2 mol% Ag2 O and the 1 mol% Ag2 O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2 O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.