Copper‐Catalyzed Amination of Congested and Functionalized α‐Bromocarboxamides with either Amines or Ammonia at Room Temperature. (15th August 2017)

• Record Type: Journal Article
• Authors: Ishida, Syo; Takeuchi, Kentaro; Taniyama, Nobuhiro; Sunada, Yusuke; Nishikata, Takashi
• Is Part Of: Angewandte Chemie. Volume 129:Number 38(2017)
• Page Start: 11768
• Page End: 11772
• Publication Date: 2017-08-15
• Subjects: Alkylierungen -- Amide -- Aminierungen -- Kupfer -- Reaktionsmechanismen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201706293
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: There are several reports on the synthesis of alkylamines, but most of the reported methods are not suitable for the synthesis of hindered amines. In this research, we found that a copper catalyst is effective for the formation of congested C−N bonds at room temperature. Control experiments revealed that a copper amide is a key intermediate. Moreover, when a chiral amine was used, a quaternary carbon stereogenic center was created with good selectivity.