Preparation of chitosan-hydroxyapatite composite mono-fiber using coagulation method and their mechanical properties. (1st November 2017)

• Record Type: Journal Article
• Authors: Okada, Takuma; Nobunaga, Yuta; Konishi, Toshiisa; Yoshioka, Tomohiko; Hayakawa, Satoshi; Lopes, Maria Ascensão; Miyazaki, Toshiki; Shirosaki, Yuki
• Is Part Of: Carbohydrate polymers. Volume 175(2017)
• Page Start: 355
• Page End: 360
• Publication Date: 2017-11-01
• Subjects: Artificial ligament -- Fiber -- Chitosan -- Hydroxyapatite -- Coagulation method -- Mechanical property; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.07.072
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: This coagulation method was successful to obtain a chitosan-HAp composite fiber. Stretching improved the orientation and maximum stress of the fibers. Swelling and degradation rate of the fibers were inhibited by HAp formation. The bone-bonding ability was confirmed in chitosan-HAp composite fibers. Abstract: Autograft has been carried out for anterior cruciate ligament (ACL) reconstruction surgery. However, it has negative aspect because patients lose their healthy ligaments from other part. We focus on a chitosan-hydroxyapatite (HAp) composite fiber as a scaffold of ligament regeneration. Chitosan- HAp composite fiber was made by using coagulation method. Chitosan-NaH2 PO4 solution was coagulated with coagulation bath including calcium ion to get the mono-fiber and then treated with sodium hydroxide solution to form HAp in fiber matrix. The mechanical property of the fiber was improved by the stretching of the wet one because of the orientation of chitosan molecule and the interaction between chitosan and HAp. Maximum stress was improved with increasing of sodium dihydrogen phosphate until 0.03 M. The swelling ratio of the fiber was inhibited by composited with HAp. Additionally, bone-bonding ability was confirmed by SBF soaking tests.