Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine. (15th October 2017)

• Record Type: Journal Article
• Authors: Yan, Jing-Kun; Wang, Yao-Yao; Qiu, Wen-Yi; Wu, Jian-Yong
• Is Part Of: Carbohydrate polymers. Volume 174(2017)
• Page Start: 209
• Page End: 216
• Publication Date: 2017-10-15
• Subjects: Curdlan sulfate -- Chitosan -- Polyelectrolyte complex -- Nanocarrier -- Zidovudine -- Drug delivery; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.06.082
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Curdlan sulfate (CRDS)-chitosan (CS) polyelectrolyte complexes (PECs) were prepared. The prepared CRDS/CS PECs showed a spherical morphology and negative zeta potential. Zidovudine (AZT) as a model drug was encapsulated into the nanosized CRDS/CS PECs. AZT showed a controlled and pH-dependent drug release from the nanosized CRDS/CS PECs. The CRDS/CS PECs can be explored as ideal nanocarriers for antiviral drug delivery. Abstract: In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construct nanosized polyelectrolyte complexes (PECs) with a polycation, chitosan (CS), via electrostatic interactions. Nanosized PECs were formed simply by mixing CRDS (0.5 mg/mL) and CS (0.5 mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180 nm and a zeta potential value of about −38 mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.