Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance. (September 2017)

• Record Type: Journal Article
• Authors: Jia, Yanjun; Luo, Xiaohe; Ji, Ying; Xie, Jingwen; Jiang, Han; Fu, Mao; Li, Xiaoqiang
• Is Part Of: Diabetes research and clinical practice. Volume 131(2017)
• Page Start: 116
• Page End: 123
• Publication Date: 2017-09
• Subjects: C1q/TNF-related protein-9 -- Adipokine -- Insulin resistance -- Type 2 diabetes mellitus; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2017.07.003
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Circulating CTRP9 level was higher in both impaired glucose intolerance and newly diagnosed T2DM than in individuals with normal glucose tolerance. Overweight subjects had higher CTRP9 levels than lean individuals, and in all subjects, females also had higher CTRP9 levels than males. Circulating CTRP9 level was positively correlated with markers of obesity and insulin resistance. Hyperglycemia during an oral glucose challenge obviously increased circulating CTRP9 concentrations. Abstract: Aims: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has been shown to promote lipid metabolism, enhance insulin sensitivity and protect against cardiovascular disease. However, previous studies in humans have produced controversial results regarding the association between CTRP9 and insulin resistance. The objective of this study was to evaluate the relationships between CTRP9 and insulin resistance in Chinese population. Methods: Subjects with normal glucose tolerance (NGT, n = 108), impaired glucose tolerance (IGT, n = 92), and newly diagnosed type 2 diabetes mellitus (nT2DM, n = 106) were recruited to determining the circulating CTRP9 and adiponectin levels by enzyme linked immunosorbent assay. Anthropometric and biochemical measurements related to insulin resistance, adiposity and lipid profile were examined for all participants. Oral glucose tolerance test was performed in healthy subjects (17 male and 17 female). Results: Circulating CTRP9 level was significantly higher in both IGT and nT2DM than in individuals with NGT. Overweight/obese subjects had much higher CTRP9 levels than lean individuals, and in all subjects, females also had higher CTRP9 levels than males. In addition, circulating CTRP9 level was positively correlated with markers of obesity and insulin resistance, including body mass index, fasting blood glucose, insulin, HbA1c, homeostasis model assessment of insulin resistance and low-density lipoprotein-cholesterol, while was inversely correlated with high-density lipoprotein-cholesterol and adiponectin. Moreover, hyperglycemia during an oral glucose challenge increased circulating CTRP9 concentrations. Conclusions: We conclude that CTRP9 was strongly associated with insulin resistance, suggesting that CTRP9 might be important in the development of type 2 diabetes.