Total glucosides of paeony for rheumatoid arthritis: A systematic review of randomized controlled trials. (October 2017)

• Record Type: Journal Article
• Authors: Luo, Jing; Jin, Di-Er; Yang, Guo-Yan; Zhang, Ying-Ze; Wang, Jian-Ming; Kong, Wei-Ping; Tao, Qing-Wen
• Is Part Of: Complementary therapies in medicine. Volume 34(2017)
• Page Start: 46
• Page End: 56
• Publication Date: 2017-10
• Subjects: Rheumatoid arthritis -- Total glucosides of paeony -- Herbal medicine -- Systematic review -- Meta-analysis; Alternative medicine -- Periodicals; Complementary Therapies -- Periodicals; Médecines parallèles -- Périodiques; Thérapeutique -- Périodiques; Alternative medicine; Electronic journals; Periodicals; 615.5
• DOI: 10.1016/j.ctim.2017.07.010
• Languages: English
• ISSNs: 0965-2299

Abstract

Highlights: This is the first PRISMA-compliant systematic review to assess the effectiveness and safety of TGP for patients with RA. In addition to measuring the methodological quality of included studies, this systematic review also evaluated the strength of evidence. TGP may be a good choice for patients with RA as an adjuvant therapy on the basis of traditional disease-modifying antirheumatic drugs. Abstract: Background: Total glucosides of paeony (TGP) is commonly used to treat rheumatoid arthritis (RA) in China. However, clinical practice hasn't been well informed by evidence from appropriately conducted systematic reviews. This PRISMA-compliant systematic review aims at examining the effectiveness and safety of TGP for RA. Methods: Randomized controlled trials (RCTs) comparing TGP with placebo, no treatment, or disease-modifying antirheumatic drugs (DMARDs) for patients with RA were retrieved by searching seven databases. Primary outcomes included disease improvement and disease remission. Secondary outcomes included adverse effects, pain, health-related quality of life, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Data extraction and analyses were conducted according to the Cochrane standards. We assessed risk of bias for each included studies and quality of evidence on pre-specified outcomes. Results: Eight studies enrolling 1209 patients with active RA were included in this systematic review. On the basis of traditional DMARD(s), TGP might be beneficial for patients with RA in improvement of American College of Rheumatology (ACR) 20 response rate, ACR 50 response rate, ACR70 response rate, and in reduction of adverse effects, compared with no treatment. The overall methodological quality of included studies and the quality of evidence for each outcome were limited. Conclusions: Current trials suggested potential benefits of TGP for RA on the basis of traditional DMARD(s). Therefore, TGP may be a good choice for RA as an adjuvant therapy. However, considering the limited methodological quality and strength of evidence, high-quality RCTs are warranted to support the use of TGP for RA.