Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors. (August 2017)

• Record Type: Journal Article
• Authors: Dammeijer, Floris; Lau, Sai Ping; van Eijck, Casper H.J.; van der Burg, Sjoerd H.; Aerts, Joachim G.J.V.
• Is Part Of: Cytokine & growth factor reviews. Volume 36(2017)
• Page Start: 5
• Page End: 15
• Publication Date: 2017-08
• Subjects: Immunotherapy -- Immune-checkpoint blockade -- Tumor immunology -- Tumor microenvironment -- Personalized medicine; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2017.06.011
• Languages: English
• ISSNs: 1359-6101

Abstract

Abstract: With the widespread application of immune checkpoint blocking antibodies (ICBs) for the treatment of advanced cancer, immunotherapy has proven to be capable of yielding unparalleled clinical results. However, despite the initial success of ICB-treatment, still a minority of patients experience durable responses to ICB therapy. A plethora of mechanisms underlie ICB resistance ranging from low immunogenicity, inadequate generation or recruitment of tumor-specific T cells or local suppression by stromal cells to acquired genetic alterations leading to immune escape. Increasing the response rates to ICBs requires insight into the mechanisms underlying resistance and the subsequent design of rational therapeutic combinations on a per patient basis. In this review, we aim to establish order into the mechanisms governing primary and secondary ICB resistance, offer therapeutic options to circumvent different modes of resistance and plea for a personalized medicine approach to maximize immunotherapeutic benefit for all cancer patients.