Intraoperative subdural low-noise EEG recording of the high frequency oscillation in the somatosensory evoked potential. Issue 10 (October 2017)

• Record Type: Journal Article
• Authors: Fedele, Tommaso; Schönenberger, Claudio; Curio, Gabriel; Serra, Carlo; Krayenbühl, Niklaus; Sarnthein, Johannes
• Is Part Of: Clinical neurophysiology. Volume 128:Issue 10(2017:Oct.)
• Page Start: 1851
• Page End: 1857
• Publication Date: 2017-10
• Subjects: High frequency oscillations -- Low-noise EEG -- Somatosensory evoked potential -- Intraoperative corticogram; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2017.07.400
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Low-noise EEG improves signal-to-noise ratio for evoked high-frequency oscillations (HFO) in subdural recording. Somatosensory evoked potential amplitude decreases with increasing stimulation rate under propofol. Somatosensory evoked potential amplitude were indistinguishable between propofol and sevoflurane anesthesia. Abstract: Objective: The detectability of high frequency oscillations (HFO, >200 Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA). Methods: In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7 Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia. Results: In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate ( p < 0.05). We detected a higher percentage of single trial evoked HFO with the LNA ( p < 0.001) for recordings with low impedance (<5 kΩ). Average amplitudes were indistinguishable between anesthesia compounds. Conclusion: Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance. Significance: Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings.