Patterns and functional implications of platelets upon tumor "education". (September 2017)

• Record Type: Journal Article
• Authors: Zhang, Qun; Liu, Hongda; Zhu, Qingqing; Zhan, Ping; Zhu, Suhua; Zhang, Jianya; Lv, Tangfeng; Song, Yong
• Is Part Of: International journal of biochemistry & cell biology. Volume 90(2017)
• Page Start: 68
• Page End: 80
• Publication Date: 2017-09
• Subjects: ADP adenosine diphosphate -- CAM cell adhesion molecule -- CLEC2 C-type lectin-like receptor-2 -- COX-2 cyclooxygenase-2 -- CTCs circulating tumor cells -- G-CSF granulocyte colony-stimulation factor -- Gp Glycoproteins -- GPCRs G Protein-coupled Receptors -- IL-1β interleukin-1β -- ILs interleukins -- LROs lysosome-related organelles -- miRNA microRNA -- MS Mass spectrometry -- NETs neutrophil extracellular DNA traps -- OCS open canalicular system -- PARs protease-activated receptors -- PDPN podoplanin (Aggrus) -- PF4 platelet factor V -- PLC phospholipase C -- PLR platelet lymphocyte ratio -- PMPs platelet microparticles -- qPCR quantitative polymerase chain reaction -- RNA-Seq RNA sequencing -- TCIPA tumor cell–induced platelet aggregation -- TF Tissue factor -- TGN trans-Golgi network -- TMs tumor microvesicles -- vWF von Willebrand factor; Circulating tumor cells (CTCs) -- Interaction -- Platelets -- Tumor "education"; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2017.07.018
• Languages: English
• ISSNs: 1357-2725

Abstract

Highlights: Platelets play important roles in carcinogenesis, tumor metastasis and tumor therapy. Tumor cells "educate" or activate platelets in different manners. Molecular and functional alterations of platelets upon tumor "education" need further elucidate. The omics approaches in mapping profiles of platelets are perspective. Abstract: While platelets are traditionally recognized to play a predominant role in hemostasis and thrombosis, increasing evidence verifies its involvement in malignancies. As a component of the tumor microenvironment, platelets influence carcinogenesis, tumor metastasis and chemotherapy efficiency. Platelets status is thus predictable as a hematological biomarker of cancer prognosis and a hot target for therapeutic intervention. On the other hand, the role of circulating tumor cells (CTCs) as an inducer of platelet activation and aggregation has been well acknowledged. The cross-talk between platelets and CTCs is reciprocal on that the CTCs activate platelets while platelets contribute to CTCs' survival and dissemination. This review covers some of the current issues related to the loop between platelets and tumor aggression, including the manners of tumor cells in "educating" platelets and biofunctional alterations of platelets upon tumor "education". We also highlight the potential clinical applications on the interplay between tumors and platelets. Further studies with well-designed prospective multicenter trials may contribute to clinical "liquid biopsy" diagnosis by evaluating the global changes of platelets.