Targeting Photochemical Scalpels or Lancets in the Photodynamic Therapy Field—The Photochemist's Role. (13th June 2017)

• Record Type: Journal Article
• Authors: Protti, Stefano; Albini, Angelo; Viswanathan, Radhika; Greer, Alexander
• Is Part Of: Photochemistry and photobiology. Volume 93:Number 5(2017)
• Page Start: 1139
• Page End: 1153
• Publication Date: 2017-06-13
• Subjects: Photochemistry -- Periodicals; Light -- Physiological effect -- Periodicals; 541.35
• DOI: 10.1111/php.12766
• Languages: English
• ISSNs: 0031-8655

Abstract

Abstract: This review covers photochemical approaches aimed at supplementing surgical instruments with handheld photodynamic therapy (PDT) instruments. PDT is not widely used in hospitals, because of the laser equipment and expertise needed, and because insurance policies often do not cover the procedure. Accordingly, this review focuses on advances in photochemistry, photophysics, nanotechnology and miniaturization techniques that may likely inspire the use of handheld instruments in PDT. A takeaway point is that the advent of photochemical scalpels or lancets that deliver reactive oxygen species (ROS) on site may better equip medical practitioners and allow for eradication of tumors or infections in general. Specifically, the review is divided into several sections: sensitizer types, multiphoton and plasmonic topics, sensitizer delivery, light delivery, dosimetry, fiber optics and handheld implements in PDT. Abstract : A handheld photodynamic therapy probe that delivers reactive oxygen species to specific sites can provide new avenues for healthcare professionals.