Ruthenium(ii) arene complexes showing DNA photobinding: the role of the basicity of the monodentate ligand. (18th August 2017)

• Record Type: Journal Article
• Authors: Chen, Yongjie; Luo, Xiaohe; Bai, Lijuan; Hu, Xuelian; Zhou, Jing; Zhang, Pu; Yu, Yu
• Is Part Of: New journal of chemistry. Volume 41:Number 18(2017)
• Page Start: 10225
• Page End: 10230
• Publication Date: 2017-08-18
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj01864a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : With a decrease in the basicity of the monodentate ligand X, the ligand photodissociation efficiencies of the complexes increase gradually. Abstract : Herein, a series of Ru(arene) complexes, [(η 6 - p -cymene)Ru(bpy)(X)] 2+ complexes (bpy = 2, 2′-bipyridine, X = pyridine, diazine, pyrimidine, and pyrazine) was synthesized, and its photochemical and photobiological properties were carefully compared. It has been found that the basicity of the monodentate ligand has a significant impact on the ligand photodissociation and photobinding DNA abilities of the complexes. A decrease in the basicity of the monodentate ligand leads to a decrease in the electron donating ability of the monodentate ligand; this enhances the photoinduced DNA covalent binding capabilities of1–4 . The CCK8 assay suggests that4 exhibits the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. By changing the basicity of the monodentate ligand, the photobinding abilities increases from the complexes1 to4 ; this provides a good strategy for the development of more efficient metallodrugs with photoactivity.