Inside Back Cover: Fabrication of Highly Stable Glyco‐Gold Nanoparticles and Development of a Glyco‐Gold Nanoparticle‐Based Oriented Immobilized Antibody Microarray for Lectin (GOAL) Assay (Chem. Eur. J. 10/2015). Issue 10 (19th February 2015)

• Record Type: Journal Article
• Authors: Huang, Li‐De; Adak, Avijit K.; Yu, Ching‐Ching; Hsiao, Wei‐Chen; Lin, Hong‐Jyune; Chen, Mu‐Lin; Lin, Chun‐Cheng
• Is Part Of: Chemistry. Volume 21:Issue 10(2015)
• Page Start: 4163
• Page End: 4163
• Publication Date: 2015-02-19
• Subjects: antibodies -- biosensors -- boronic acid -- nanoparticles -- lectins; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.403479
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Aqueous dispersions of multivalent glyco–gold nanoparticles featuring mixed thiolated ligands, glycan and an amphiphilic linker are not only stable at high ionic strength, but are also highly resistant to nonspecific protein adsorption. These features establish a simple but powerful lectin sensing strategy for probing the binding of glycans to proteins on boronic acid‐derivatized surfaces, namely the GOAL assay that permits nanomolar level detection of model plant lectins by the naked eye. For more details, see the Full Paper by C.‐C. Lin et al. onpage 3956 ff.