CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides. Issue 35 (29th August 2017)

• Record Type: Journal Article
• Authors: Li, Die; Wu, Xin-Xing; Gao, Tingyu; Li, Baoguo; Chen, Shufeng
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 35(2017)
• Page Start: 7282
• Page End: 7285
• Publication Date: 2017-08-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01838j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. Abstract : An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. The distinctive features of this protocol include the use of an inexpensive copper salt as a catalyst, simple and readily available starting materials, and ligand-free conditions. An important application of this method to the synthesis of 1, 3-diene substituted benzoxazoles has also been achieved.