Copper-catalyzed decarboxylative methylthiolation of aromatic carboxylate salts with DMSO. Issue 27 (27th June 2017)

• Record Type: Journal Article
• Authors: Hu, Liang; Wang, Dadian; Chen, Xiang; Yu, Lin; Yu, Yongqi; Tan, Ze; Zhu, Gangguo
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 27(2017)
• Page Start: 5674
• Page End: 5679
• Publication Date: 2017-06-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01315a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Abstract : A novel copper-catalyzed decarboxylative methylthiolation of arenecarboxylate salts has been realized using DMSO as the methylthiolation source. Various potassium aryl carboxylates underwent decarboxylative methylthiolation under air to furnish the corresponding aryl methyl thioethers in moderate to excellent yields. The reaction tolerated a wide variety of functional groups. Notably, the synthesis of ethylthioethers was also successfully achieved directly from diethyl sulfoxide under similar reaction conditions.