High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus). (2nd November 2017)

• Record Type: Journal Article
• Authors: He, Xiaohong; Chen, Xiaofei; Zhang, Wenbin; Pu, Yabin; Song, Shen; Han, Jianlin; Dong, Kunzhe; Zhao, Qianjun; Guan, Weijun; Ma, Yuehui; Jiang, Lin
• Is Part Of: Mitochondrial DNA. Volume 28:Number 6(2017)
• Page Start: 851
• Page End: 854
• Publication Date: 2017-11-02
• Subjects: Bactrian camel -- control region -- length heteroplasmy -- mitochondrial DNA
• DOI: 10.1080/24701394.2016.1197219
• Languages: English
• ISSNs: 2380-2359

Abstract

Abstract: Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.