Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4. Issue 74 (1st September 2017)
- Record Type:
- Journal Article
- Title:
- Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4. Issue 74 (1st September 2017)
- Main Title:
- Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4
- Authors:
- Guidotti, Nora
Lechner, Carolin C.
Fierz, Beat - Abstract:
- Abstract : We describe the iso lnc-tag, a traceless, protease-removable internal crosslinking tag, to control the assembly of nucleosomes asymmetrically modified on H4. Abstract : In stem cells, H4 proteins carrying different modifications coexist within single nucleosomes. For functional studies, we report the synthesis of such asymmetric nucleosomes. Asymmetry is achieved by transiently crosslinking H4 by a traceless, protease-removable tag introduced via an isopeptide linkage. These nucleosomes are used to study Set8 activity, a key methyltransferase.
- Is Part Of:
- Chemical communications. Volume 53:Issue 74(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 74(2017)
- Issue Display:
- Volume 53, Issue 74 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 74
- Issue Sort Value:
- 2017-0053-0074-0000
- Page Start:
- 10267
- Page End:
- 10270
- Publication Date:
- 2017-09-01
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c7cc06180c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 4594.xml