Glycosylation Chemistry of 3‐Deoxy‐D‐manno‐Oct‐2‐ulosonic Acid (Kdo) Donors. Issue 3 (10th February 2015)

• Record Type: Journal Article
• Authors: Pradhan, Tapan Kumar; Mong, Kwok Kong Tony
• Is Part Of: Israel journal of chemistry. Volume 55:Issue 3/4(2015)
• Page Start: 285
• Page End: 296
• Publication Date: 2015-02-10
• Subjects: capsular polysaccharides -- isomers -- 3‐deoxy‐D‐manno‐oct‐2‐ulosonic acid -- glycosylation -- lipopolysaccharides; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.201400145
• Languages: English
• ISSNs: 0021-2148

Abstract

Abstract: 3‐Deoxy‐D ‐manno‐Oct‐2‐ulosonic acid (Kdo)‐containing oligosaccharides are a conserved carbohydrate component in lipopolysaccharides (LPSs) of the outer membrane of Gram‐negative bacteria, and they are also present in capsular polysaccharides (CPSs) of bacteria and plant cells. The association of the bacterial LPS with the pathophysiology of bacterial infection have long been recognized. Structurepathophysiology studies of bacterial infection need to use pure and homogeneous LPS fragments. Such a requirement can be fulfilled by the synthesis of Kdo glycosides and related Kdooligosaccharide conjugates. This article provides an overview of the glycosylation chemistries of the synthesis of Kdo α‐/β‐glycosides, oligosaccharides with Kdo units such as LPS core oligosaccharides, and lipid A derivatives. Abstract :