Glucose metabolism of visceral adipose tissue measured by 18F-FDG PET/CT is related to the presence of colonic adenoma. Issue 25 (June 2017)

• Record Type: Journal Article
• Authors: Yoon, Hai-Jeon; Kim, Bom Sahn; Lee, Ko Eun; Moon, Chang Mo; Yoo, Jang; Kim, Jung-Sook; Kim, Yemi
• Other Names: Masoomi. Michael section editor.
• Is Part Of: Medicine. Volume 96:Issue 25(2017)
• Publication Date: 2017-06
• Subjects: colonic adenoma -- fluorodeoxyglucose positron emission tomography/computed tomography -- glucose metabolism -- visceral adipose tissue; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000007156
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: This study investigated the relationships between the area and metabolic activity of adipose tissue and the presence of colorectal adenoma (CRA). Our institutional review board approved the study and waived informed consent. A total of 212 subjects who underwent fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and colonoscopy for routine health check-ups were enrolled. The volumetric parameters of areas of visceral (VAT av ), subcutaneous (SAT av ), and total adipose tissue (TAT av ) and calculated visceral-to-subcutaneous adipose tissue ratio (VSR) and visceral-to-total adipose tissue ratio (VAR) were considered. Metabolic parameters of standardized uptake value (SUV) of visceral ( vc SUV max, vc SUV mean ), subcutaneous ( sc SUV max, sc SUV mean ), and calculated visceral-to-subcutaneous adipose tissue ratio (VSR max, VSR mean ) were considered. Anthropometric data of height, weight, body mass index (BMI), waist circumference (WC), body fat mass (BFM), skeletal muscle mass (SMM), and diverse laboratory data were also considered as variables. Sixty-six subjects were placed in the CRA group and 146 subjects in the non-CRA group. The presence of CRA was significantly correlated with older age ( P = .001), male sex ( P = .041), higher BMI ( P = .004), higher WC ( P = .001), higher BFM ( P = .024), higher VAT av ( P < .001), higher TAT av ( P = .004), higher VSR ( P < .001), higher VAR ( P < .001), lower vc SUV max ( P = .002), lower vc SUV mean ( P < .001), and lower VSR mean ( P = .002). On multiple regression analysis, vc SUV max and vc SUV mean were independently associated with the presence of CRA ( P = .009 and P = .045). Lower glucose metabolism of visceral adipose tissue was related to the presence of CRA. Our findings identify the value of visceral metabolic dysfunction as a potential surrogate marker of elevated risk for CRA. Abstract : Supplemental Digital Content is available in the text