Frontispiece: Enzymatic Halogenation: A Timely Strategy for Regioselective C−H Activation. Issue 50 (7th September 2017)

• Record Type: Journal Article
• Authors: Schnepel, Christian; Sewald, Norbert
• Is Part Of: Chemistry. Volume 23:Issue 50(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-09-07
• Subjects: biocatalysis -- halogenase -- one-pot synthesis -- oxidoreductase -- protein engineering; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201785065
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : C−H functionalization belongs to the most challenging topics of synthetic chemistry due to the dilemma of substrate vs. catalyst control. Remarkably, halogenating enzymes provide a "green" approach for site‐selective C–H functionalization that is often superior to conventional methodologies. Only molecular oxygen and halide salts are required for highly selective electrophilic halogenation under ambient conditions. Recently considerable efforts were made to enhance the preparative utility of halogenating enzymes. The application scope was expanded towards more robust biocatalysts enabling enzymatic halogenation of a wide range of arenes. Timely developments of biohalogenation regarding preparative synthesis, engineering and cascade processes are being discussed in the minireview by C. Schnepel and N. Sewald onpage 12064 ff.