Preparation of Au/silica/poly(ethylene glycol) nanoparticle colloid solution and its use in x-ray imaging process. Issue 2 (29th April 2015)

• Record Type: Journal Article
• Authors: Kobayashi, Yoshio; Nagasu, Ryoko; Nakagawa, Tomohiko; Kubota, Yohsuke; Gonda, Kohsuke; Ohuchi, Noriaki
• Is Part Of: Nanocomposites. Volume 1:Issue 2(2015)
• Page Start: 83
• Page End: 88
• Publication Date: 2015-04-29
• Subjects: Au -- Silica -- Core–shell -- Nanoparticle -- Poly(ethylene glycol) -- X-ray contrast agent; Nanocomposites (Materials) -- Periodicals; 620.11805
• DOI: 10.1179/2055033215Y.0000000003
• Languages: English
• ISSNs: 2055-0324

Abstract

Abstract: In this work, the authors performed X-ray imaging of mice using a colloid solution of Au nanoparticles that are coated with silica and subsequently surface-modified with poly(ethylene glycol) (PEG) (Au/SiO2 /PEG). The silica-coating for Au nanoparticles and the amination for silica-coated particles were simultaneously performed in the presence of the Au nanoparticles, which were prepared by reducing Au ions (III) with sodium citrate in water at 80°C and by surface-modifying the Au nanoparticles with (3-aminopropyl)-trimethoxysilane (APMS), by a sol–gel process using tetraethylorthosilicate (TEOS), (3-aminopropyl)-triethoxysilane, water and sodium hydroxide (Au/SiO2 -NH2 ). The surface modification of Au/SiO2 -NH2 particles with PEG was performed by simply adding PEG with a functional group that reacts with an amino group to the Au/SiO2 -NH2 particle colloid solution. A computed tomography value of the Au/SiO2 /PEG colloid solution with an Au concentration of 0.129M was as high as 895 ± 8 HU. Mouse tissues were imaged following injection of the Au/SiO2 /PEG particle colloid solution. Abstract :