An electroamalgamation approach to separate 47Sc from neutron-activated 46Ca target for use in cancer theranostics. Issue 14 (22nd September 2017)

• Record Type: Journal Article
• Authors: Chakravarty, Rubel; Chakraborty, Sudipta; Ram, Ramu; Dash, Ashutosh
• Is Part Of: Separation science and technology. Volume 52:Issue 14(2017)
• Page Start: 2363
• Page End: 2371
• Publication Date: 2017-09-22
• Subjects: 47Sc -- 47Sc-DOTA-TATE -- cancer -- electroamalgamation -- radiochemical separation -- theranostics; Separation (Technology) -- Periodicals; 660.284205
• DOI: 10.1080/01496395.2017.1295994
• Languages: English
• ISSNs: 0149-6395

Abstract

ABSTRACT: Scandium-47 [T½ = 3.35 d, Eβ- (max.) = 600 keV, Eγ = 159 keV] is a relatively new radioisotope that holds tremendous potential for use in cancer theranostics. The radioisotope was produced by thermal neutron irradiation of enriched 46 Ca producing 47 Ca, which decays by β − emission to 47 Sc. A viable method based on the selective electroamalgamation of Ca 2+ ions has been developed for the clinical-scale separation of 47 Sc from 47 Ca. The overall yield of 47 Sc after the separation process was >80% and it was obtained with >99.9% radionuclidic purity in a form suitable for radiopharmaceutical preparation. This strategy holds promise for future clinical translation of this radioisotope.