Taxanes from Taxus wallichiana var. mairei cultivated in the southern area of the Yangtze River in China. Issue 20 (18th October 2017)

• Record Type: Journal Article
• Authors: Lun, Bo-Shu; Shao, Li-Wei; Wang, Yong; Li, Cong-Cong; Yu, Hua; Wang, Chun-Hua; Zhu, Yan
• Is Part Of: Natural product research. Volume 31:Issue 20(2017)
• Page Start: 2341
• Page End: 2347
• Publication Date: 2017-10-18
• Subjects: Taxane -- Taxus wallichiana var. mairei -- cytotoxic effect -- MCF-7, Bioactive compound -- Bioactive compound; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1305381
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new and 25 known taxane diterpenoids were isolated from the dried whole plants of Taxus wallichiana var. mairei cultivated in the southern area of the Yangtze River in China. The chemical structure of new compound1, named taxiwallinine, was established by means of MS and NMR analyses. Among the 25 known taxane compounds2–26, compounds10, 12, 14, 15, 17 and21–23 were first isolated from this plant. Taxiwallinine and taxol were screened for the cytotoxic effect on human breast cancer cell line MCF-7 with IC50 values of 20.898 μg/mL and 0.008 μg/mL, respectively. Taxiwallinine showed moderate cytotoxicity to this cell line. These results demonstrate that T. wallichiana var. mairei cultivated in the southern area of the Yangtze River in China could be a renewable resource for extracting the taxane derivatives and the new compound, taxiwallinine, could be a potential anti-tumour product. Abstract :