Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings. (3rd July 2017)

• Record Type: Journal Article
• Authors: Lucovnik, Miha; Lackner, Helmut Karl; Papousek, Ilona; Schmid-Zalaudek, Karin; Schulter, Guenter; Roessler, Andreas; Moertl, Manfred Georg
• Is Part Of: Hypertension in pregnancy. Volume 36:Number 3(2017)
• Page Start: 276
• Page End: 281
• Publication Date: 2017-07-03
• Subjects: ADMA -- case-control methodology -- nitric oxide synthesis -- preeclampsia -- SDMA; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2017.1364381
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objective: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. Methods: Twenty-four preeclamptic patients (14 at ≥ 34 weeks') and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay . Results: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. Conclusions: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors.