Therapeutic advances in dystonia. Issue 11 (24th August 2015)

• Record Type: Journal Article
• Authors: Albanese, Alberto; Romito, Luigi M.; Calandrella, Daniela
• Other Names: Goetz C.G. guestEditor.; Poewe W. guestEditor.
• Is Part Of: Movement disorders. Volume 30:Issue 11(2015)
• Page Start: 1547
• Page End: 1556
• Publication Date: 2015-08-24
• Subjects: dystonia -- treatment -- medication -- surgery -- botutinum toxins -- deep brain stimulation; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26384
• Languages: English
• ISSNs: 0885-3185

Abstract

Abstract: Knowledge on dystonia has greatly improved recently, because of a renewed effort in understanding its cause, pathophysiology, and clinical characterization. Different drug classes traditionally have been used for the symptomatic treatment of dystonia, more recently surpassed by the introduction of botulinum neurotoxins and deep brain stimulation. No curative or disease‐modifying treatments are available. Recent knowledge regarding the pathophysiology of inherited dystonias is highlighting new potential treatment strategies. We review therapeutic advances in dystonia that have been published over the last 3 years, particularly regarding oral medications, local injections of botulinum neurotoxins, deep brain stimulation, and transcranial or epidural brain stimulations. We discuss evidence of efficacy, highlight recent advances, and focus on key areas under development. © 2015 International Parkinson and Movement Disorder Society