A compendium of ERK targets. Issue 17 (25th July 2017)

• Record Type: Journal Article
• Authors: Ünal, Evrim B.; Uhlitz, Florian; Blüthgen, Nils
• Other Names: Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 591:Issue 17(2017)
• Page Start: 2607
• Page End: 2615
• Publication Date: 2017-07-25
• Subjects: ERK targets -- MAP kinase signaling -- phosphorylation -- RAF‐MEK‐ERK; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12740
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The RAF‐MEK‐ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort to determine ERK target proteins involved in regulating these programs. Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho‐proteomic technologies, numerous studies have expanded the number of ERK target proteins. Here, we compile a comprehensive ERK target phospho‐site archive, in which we gathered information from various research studies, and we provide this archive as an online database to form a searchable compendium of ERK targets. Abstract :